Also known as: IBI362 • LY3305677
Peptide Class: Dual GLP‑1 / Glucagon Receptor Agonist

Mazdutide is a next‑generation synthetic peptide designed to model the activity of oxyntomodulin, a naturally occurring metabolic hormone. Engineered as a dual agonist of both the GLP‑1 and glucagon receptors, Mazdutide allows researchers to explore multi‑pathway metabolic signaling in a controlled laboratory environment.

This high‑purity, research‑grade peptide supports investigations into mechanisms related to energy balance, glucose regulation, appetite signaling, and thermogenic pathways.

Key Research Features

Dual‑Receptor Engagement

Mazdutide activates both the GLP‑1 and glucagon receptors, providing a unique tool for studying combined incretin and glucagon pathway modulation. This dual mechanism supports research into synergistic metabolic effects not accessible through single‑agonist compounds.

Oxyntomodulin‑Inspired Architecture

Designed as a synthetic analog of oxyntomodulin, Mazdutide enables structured experimentation into metabolic hormone mimicry and receptor specificity.

Engineered for Extended Activity

Its optimized peptide structure—including long‑chain lipid conjugation in reference materials—supports prolonged stability and experimental usefulness in lab settings.

Research Applications

Mazdutide is commonly used in advanced metabolic research such as:

• Investigating energy expenditure and thermogenesis
• Exploring appetite‑signaling pathways
• Modeling glucose and insulin‑related metabolic processes
• Comparative studies involving incretin‑class multi‑agonist peptides
• Research on metabolic rate, lipid oxidation, and nutrient sensing

Its broad metabolic profile makes Mazdutide a valuable tool for modern studies focused on weight‑related, glycemic, and energetic pathways.

Why Researchers Choose Mazdutide

• First‑of‑its‑kind dual GLP‑1/glucagon receptor model peptide
• Broad metabolic pathway engagement for complex study designs
• Consistent, high‑purity material suitable for controlled in vitro assays
• Useful for both single‑pathway and multi‑pathway comparative studies
• Mechanistically aligned with next‑generation metabolic research compounds

Intended Use

Mazdutide is not a drug, supplement, or injectable, and is not approved for human or animal consumption.
It is provided exclusively for laboratory research and in vitro applications.